Visible-light-enabled cascade cross-dehydrogenative-coupling/cyclization to construct α-chromone substituted α-amino acid derivatives
Zhi‐Qiang Zhu, Jiayu Hu, Zongbo Xie, Zhanggao Le
Abstract
-hydroxyarylenaminones to afford the corresponding 3-aminoalkyl chromones in good to excellent yields. This approach consists of visible-light-promoted oxidation of α-amino acid derivatives, the Mannich reaction, and intramolecular nucleophilic cyclization under acidic conditions, and features a wide reaction scope, a simple operation and mild reaction conditions, which may have the potential to be used for the synthesis of bioactive molecules.
Topics & Concepts
ChromoneChemistryCascade reactionCascadeAmino acidCombinatorial chemistryIntramolecular forceCoupling reactionMoleculeOrganic chemistryPhotochemistryCatalysisBiochemistryChromatographyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSynthesis of Organic Compounds