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HPF1-dependent histone ADP-ribosylation triggers chromatin relaxation to promote the recruitment of repair factors at sites of DNA damage

Rebecca Smith, Siham Zentout, Magdalena B. Rother, Nicolas Bigot, Catherine Chapuis, Alexandra Mihuț, Florian Zobel, Ivan Ahel, Haico van Attikum, Gyula Timinszky, Sébastien Huet

2023Nature Structural & Molecular Biology75 citationsDOIOpen Access PDF

Topics & Concepts

ChromatinHistonePARP1DNA repairADP-ribosylationCell biologyDNA damageHistone H2ANucleosomeBiologyPoly ADP ribose polymeraseDNAPolymeraseChemistryMolecular biologyBiochemistryNAD+ kinaseEnzymePARP inhibition in cancer therapyDNA Repair MechanismsToxin Mechanisms and Immunotoxins
HPF1-dependent histone ADP-ribosylation triggers chromatin relaxation to promote the recruitment of repair factors at sites of DNA damage | Litcius