Icariin-loaded sulfonated polyetheretherketone with osteogenesis promotion and osteoclastogenesis inhibition properties <i>via</i> immunomodulation for advanced osseointegration
Haobu Chai, Shang Sang, Yao Luo, Renke He, Xiangwei Yuan, Xianlong Zhang
Abstract
experiments further showed that ICA-PDA@SPEEK regulated the host immune response and promoted osseointegration in ovariectomized (OVX) rats. The above results demonstrated that ICA-PDA@SPEEK could be an excellent orthopedic biomaterial with immunomodulatory properties.
Topics & Concepts
IcariinOsseointegrationOsteoclastMaterials scienceChemistryCell biologyMedicineBiochemistryBiologyIn vitroSurgeryImplantPathologyAlternative medicineBone Metabolism and DiseasesMedicinal Plant Pharmacodynamics ResearchOrthopaedic implants and arthroplasty