Expanding the chemical and therapeutic landscape of 5H-Indeno[1,2-b]pyridin-5-one derivatives: Novel anticancer activity, EGFR inhibition, and modulation of HIF–VEGF and PI3K/AKT/mTOR pathways supported by computational insights
Hagar S. El-Hema, Hadeer A. El-Shazly, Mohamed A. Hawata, N. M. Yousif, Modather F. Hussein, Mohamed Said, EsraaA. Aidy, Haitham E. Shehata, Adel A.‐H. Abdel‐Rahman
Topics & Concepts
ChemistryCytotoxicityEGFR inhibitorsFlow cytometryPTENDocking (animal)Cell cultureMTT assayCrosstalkMolecular dynamicsEpidermal growth factor receptorCancer cellStructure–activity relationshipCancer researchBiochemistryCell growthIn vitroMolecular modelAngiogenesisBiophysicsApoptosisProtein–protein interactionCellSelectivityLead compoundHydrogen bondPotencyStereochemistrySignal transductionIn silicoEnzymeSmall moleculeLigand (biochemistry)Growth inhibitionComputational biologyPlasma protein bindingFlavonoidCancer, Hypoxia, and MetabolismLung Cancer Treatments and MutationsCytokine Signaling Pathways and Interactions