Feasibility of a portable optical coherence tomography system in children with craniosynostosis
Ravi Purohit, Sohaib R. Rufai, Chetan K. Patel, Gregory P.L. Thomas, Owase Jeelani, D. J. Johnson, Tim Lawrence
Abstract
Craniosynostosis is characterised by the premature fusion of cranial sutures and can be associated with intracranial hypertension (IH), which can damage the brain and vision if left unaddressed The gold standard method for measuring intracranial pressure (ICP) is invasive ICP monitoring, requiring hospital admission, general anaesthesia and risks such as bleeding and infection Optical coherence tomography (OCT) is a non-invasive imaging technique providing ultra-high resolution cross-sectional images of the optic nerve within seconds. OCT has demonstrated promise as a noninvasive surrogate marker for IH, but standard table-mounted OCT devices are difficult to use in infants and young children Here, we assessed the feasibility of a portable OCT device (Fig.