Early testicular maturation is sensitive to depletion of spermatogonial pool in sickle cell disease
Klara M. Benninghoven-Frey, Nina Neuhaus, Atte Lahtinen, Claudia Krallmann, Joana M. D. Portela, Andrea Jarisch, Verena Nordhoff, Armin Soave, Hajar A.M. Ba Omar, Mikael Sundin, Cecilia Langenskiöld, Sabine Kliesch, Jan‐Bernd Stukenborg, Kirsi Jahnukainen
Abstract
ATS indicates acute thorax syndrome; FI: feritlity index; S/T: spermatogonia per round tubular cross-section; Hb: hemoglobin; HbF: fetal hemoglobin; HbS: sickle hemoglobin; HU: hydroxyurea; y: year; x d: per day; LDH: lactate dehydrogenase; MCV: mean corpuscular volume; P: P-value and r, Spearman correlation coefficient. *P<0.05. Washout period of 2 weeks -4 months was used prior to biopsy for three HU-exposed patients. All 3 patients received transfusions.
Topics & Concepts
DiseaseCellBiologyPhysiologyAndrologyMedicineImmunologyInternal medicineGeneticsHemoglobinopathies and Related DisordersIron Metabolism and DisordersPrenatal Screening and Diagnostics