Metabolomics-based phenotypic screens for evaluation of drug synergy via direct-infusion mass spectrometry
Xiyuan Lu, G. Lavender Hackman, Achinto Saha, Atul Rathore, Meghan Collins, Chelsea Friedman, S. Stephen Yi, Fumio Matsuda, John DiGiovanni, Alessia Lodi, Stefano Tiziani
Abstract
. The proposed unbiased metabolomics screening platform can be used to rapidly generate phenotype-informed datasets and quantify synergy for combinatorial drug discovery.
Topics & Concepts
MetabolomicsPhenomicsComputational biologyUnivariateDrugPhenotypic screeningDrug discoveryPharmacologyChemistryBioinformaticsMultivariate statisticsComputer scienceMedicinePhenotypeBiologyGenomicsMachine learningGenomeBiochemistryGeneMetabolomics and Mass Spectrometry StudiesMass Spectrometry Techniques and ApplicationsAnalytical Chemistry and Chromatography