A photothermally antibacterial Au@Halloysite nanotubes/lignin composite hydrogel for promoting wound healing
Xiaobo Xu, Yeyan Chao, Xiaozhen Ma, Hua Zhang, Jing Chen, Jin Zhu, Jing Chen
Abstract
The construction of an effective antibacterial micro-environment to prevent infection and biofilm formation is critically important for the design of wound dressings . Herein, a novel hydrogel wound dressing was fabricated by embedding Au nanoparticles-decorated halloysite nanotubes (Au@HNTs) into the lignin-based hydrogel matrix containing polyvinyl alcohol and chitosan. The resulting composite hydrogel, noted as LPC-Au@HNTs, exhibited an excellent photothermal antibacterial activity owing to the embedded Au@HNTs in which Au nanoparticles were generously filled into the lumen of Halloysite nanotubes . The typical sample containing 4 wt% of Au@HNTs in the composite hydrogel (LPC-Au@HNTs4) had good mechanical and photothermal properties. The surface temperature of as-prepared hydrogel increased to 57.59 °C after 5 min upon NIR light irradiation (808 nm) at 1.0 W/cm 2 . The photothermal effect endowed the hydrogel dressing with excellent antibacterial activity, with significantly enhanced inhibition rates of Escherichia coli (99.00 %) and Staphylococcus aureus (98.88 %). Experiments in a mouse full-thickness skin defect wound model also showed that the hydrogel dressing had a facilitative effect on the repair of traumatic surfaces. This study provides a broadly appliable wound dressing for treating bacteria-infected wounds, greatly contributing to the design of photothermal antibacterial biomedical materials for wound healing .