Synthesis and evaluation of FAK inhibitors with a 5-fluoro-7H-pyrrolo[2,3-d]pyrimidine scaffold as anti-hepatocellular carcinoma agents
Hanyi Tan, Yue Liu, Chaochao Gong, Jiawei Zhang, Jian Huang, Qian Zhang
Topics & Concepts
ChemistryCell growthHepatocellular carcinomaPyrimidineFocal adhesionCancer researchIn vivoPhosphorylationStereochemistryBiochemistryBiologyBiotechnologyCell Adhesion Molecules ResearchUbiquitin and proteasome pathwaysAngiogenesis and VEGF in Cancer