New Cytotoxic Cytochalasans from a Plant-Associated Fungus Chaetomium globosum kz-19
Tantan Li, Yun Wang, Li Li, Mengyue Tang, Qinghong Meng, Cun Zhang, Erbing Hua, Yue‐Hu Pei, Yi Sun
Abstract
Four new cytochalasans, phychaetoglobins A–D (1–4), together with twelve known cytochalasans (5–16), were isolated from a mangrove-associated fungus Chaetomium globosum kz-19. The new structures were elucidated on the basis of extensive 1D and 2D NMR, HR ESIMS spectroscopic analyses, and electronic circular dichroism (ECD) calculations. The absolute configuration of 2 was established by application of Mosher’s method. Compounds 4–8 exhibited moderate cytotoxicities against A549 and HeLa cell lines with the IC50 values less than 20 μM.
Topics & Concepts
Chaetomium globosumHeLaFungusStereochemistryAbsolute configurationCircular dichroismChaetomiumCytotoxic T cellMangroveTwo-dimensional nuclear magnetic resonance spectroscopyChemistryBotanyBiologyBiochemistryCellIn vitroEcologyPenicilliumMicrobial Natural Products and BiosynthesisGenomics and Phylogenetic StudiesMicrobial Community Ecology and Physiology