CFTR-beyond the airways: Recent findings on the role of the CFTR channel in the pancreas, the intestine and the kidneys
Péter Hegyi, Ursula Seidler, Karl Kunzelmann
Abstract
With increased longevity of patients suffering from cystic fibrosis, and widespread lung transplantation facilities, the sequelae of defective CFTR in other organs than the airways come to the fore. This minireview highlights recent scientific progress in the understanding of CFTR function in the pancreas, the intestine and the kidney, and explores potential therapeutic strategies to combat defective CFTR function in these organs.
Topics & Concepts
Cystic fibrosisMedicinePancreasLungLung transplantationKidneyLung functionIntensive care medicinePathologyInternal medicineCystic Fibrosis Research AdvancesNeonatal Respiratory Health ResearchEsophageal and GI Pathology