Silver-catalyzed monofluoroalkylation of heteroarenes with α-fluorocarboxylic acids: an insight into the solvent effect
Chunfang Guo, Zhaolong Liu, Xiangye Li, Xiangye Li, Xuliang Han, Yueyun Li, Hui Liu, Lizhi Zhang, Xinjin Li, Xinjin Li, Yunhui Dong
Abstract
A mild and efficient method for direct C-H monofluoroalkylation of heteroarenes with easily accessible and inexpensive α-fluorocarboxylic acids has been developed. This silver-catalyzed reaction affords mono- and bis-monofluoroalkylated heteroarenes in good yields under mild conditions, and the solvent effect on the monofluoroalkylation reaction is discussed in detail.
Topics & Concepts
CatalysisSolventChemistryReaction conditionsCombinatorial chemistryOrganic chemistryFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsInorganic Fluorides and Related Compounds