SsrA-based design of BacPROTACs for β-lactamase degradation in Gram-negative bacteria
Qiang Nie, Jessie Wing-Yin Wu, Kun Zhang, Shu Ling Lin, Carmen Oi Kwan Law, Ying Ying Zhang, Xuehan Wang, Yanjuan Gu, Zhong‐Ping Yao, Wing‐Tak Wong, Terrence Chi‐Kong Lau
Abstract
SsrA-based BacPROTACs leverage ClpXP protease to degrade the CTX-M-14 β-lactamase, restoring cefotaxime efficacy and enabling controllable bacterial protein elimination.
Topics & Concepts
GramGram-negative bacteriaBacteriaDegradation (telecommunications)MicrobiologyChemistryGram-positive bacteriaBiologyEscherichia coliAntibioticsBiochemistryComputer scienceGeneticsGeneTelecommunicationsPeptidase Inhibition and AnalysisCancer therapeutics and mechanismsAntibiotic Resistance in Bacteria