Monte Carlo Simulations Reveal New Design Principles for Efficient Nanoradiosensitizers Based on Nanoscale Metal–Organic Frameworks
Ziwan Xu, Kaiyuan Ni, Jianming Mao, Taokun Luo, Wenbin Lin
Abstract
Nanoscale metal-organic frameworks (nMOFs) have recently been shown to provide better radiosensitization than solid nanoparticles (NPs) when excited with X-rays. Here, a Monte Carlo simulation of different radiosensitization effects by NPs and nMOFs using a lattice model consisting of 3D arrays of nanoscale secondary building units (SBUs) is reported. The simulation results reveal that lattices outperform solid NPs regardless of radiation sources or particle sizes via enhanced scatterings of photons and electrons within the lattices. Optimum dose enhancement can be achieved by tuning SBU size and inter-SBU distance.
Topics & Concepts
Materials scienceNanoscopic scaleMonte Carlo methodMetal-organic frameworkNanoparticlePhotonSBusNanotechnologyPhysicsOpticsPhysical chemistryMathematicsChemistryAdsorptionStatisticsRadiation Shielding Materials AnalysisLuminescence Properties of Advanced MaterialsRadiation Detection and Scintillator Technologies