Clinical analysis of relapsing polychondritis with airway involvement
S-Y Zhai, R-Y Guo, C Zhang, C-M Zhang, H-Y Yin, B-Q Wang, S-X Wen
Abstract
Abstract Objective To identify the clinical characteristics, treatment, and prognosis of relapsing polychondritis patients with airway involvement. Methods Twenty-eight patients with relapsing polychondritis, hospitalised in the First Hospital of Shanxi Medical University between April 2011 and April 2021, were retrospectively analysed. Results Fifty per cent of relapsing polychondritis patients with airway involvement had a lower risk of ear and ocular involvement. Relapsing polychondritis patients with airway involvement had a longer time-to-diagnosis ( p < 0.001), a poorer outcome following glucocorticoid combined with immunosuppressant treatment ( p = 0.004), and a higher recurrence rate than those without airway involvement ( p = 0.004). The rates of positive findings on chest computed tomography and bronchoscopy in relapsing polychondritis patients with airway involvement were 88.9 per cent and 85.7 per cent, respectively. Laryngoscopy analysis showed that 66.7 per cent of relapsing polychondritis patients had varying degrees of mucosal lesions. Conclusion For relapsing polychondritis patients with airway involvement, drug treatment should be combined with local airway management.