Discovery of new sulfonamide-tethered 2-aryl-4-anilinoquinazolines as the first-in-class dual carbonic anhydrase and EGFR inhibitors
Wagdy M. Eldehna, Zainab M. Elsayed, Andrea Ammara, Mahmoud A. El Hassab, Hadia Almahli, Mohamed Farès, Alessio Nocentini, Claudiu T. Supuran, Sahar M. Abou‐Seri
Topics & Concepts
Carbonic anhydraseChemistrySulfanilamideSulfonamideQuinazolineCarbonic anhydrase IICombinatorial chemistrySmall moleculeStereochemistryEnzymeBiochemistryEnzyme function and inhibitionSynthesis and Catalytic ReactionsPhenothiazines and Benzothiazines Synthesis and Activities