Ceramide synthase 6 predicts poor prognosis and activates the AKT/mTOR/4EBP1 pathway in high-grade serous ovarian cancer.
Yinong Shi, Chen Zhou, Huan Lu, Xiaoxiao Cui, Jun Li, Shu‐Heng Jiang, Hao Zhang, Rong Zhang
Abstract
CerS6 may have an oncogenic role in ovarian cancer and may represent a new prognostic marker and therapeutic target for serous ovarian cancer.
Topics & Concepts
Ovarian cancerCancer researchGene knockdownMetastasisPI3K/AKT/mTOR pathwayProtein kinase BSerous fluidCell growthBiologyCancerOncologyInternal medicineMedicineSignal transductionApoptosisCell biologyGeneticsCancer Mechanisms and TherapyGenomics, phytochemicals, and oxidative stressSphingolipid Metabolism and Signaling