Aqueous-based electrospun P(NIPAAm-<i>co</i>-AAc)/RSF medicated fibrous mats for dual temperature- and pH-responsive drug controlled release
Juan Li, Jingxin Zhu, Lan Jia, Yanlong Ma, Haijuan Wu
Abstract
crosslinking and water-annealing process, the water-stable composite fibrous mats were obtained. Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) were used to analyze the crosslinking process. Temperature and pH dual stimuli-responsive swelling-shrinking behavior of the fibrous mats were observed when the temperature was below and above the LCST of the copolymer at different pHs. In addition, rhodamine B-loaded the fibrous mats also showed dual temperature and pH controlled release behavior, demonstrating the potential use of the fibrous mats for "smart" controlled drug delivery applications.
Topics & Concepts
Aqueous solutionDual (grammatical number)ChemistryChemical engineeringDrugElectrospinningNuclear chemistryMaterials scienceComposite materialPharmacologyPolymerOrganic chemistryMedicineEngineeringLiteratureArtElectrospun Nanofibers in Biomedical ApplicationsSilk-based biomaterials and applicationsAdvanced Sensor and Energy Harvesting Materials