Upregulation of transcription factor 4 downregulates NaV1.8 expression in DRG neurons and prevents the development of rat inflammatory and neuropathic hypersensitivity
Ningbo Li, Baowen Liu, Wenyao Wu, Yishun Hong, Jin Zhang, Yi Liu, Mi Zhang, Xianwei Zhang, Guangyou Duan
Topics & Concepts
Chromatin immunoprecipitationDorsal root ganglionNeuropathic painDownregulation and upregulationTCF4MedicineChronic painSodium channelATF3Transcription factorCancer researchMolecular biologyEnhancerGene expressionChemistryPharmacologyBiologyPromoterSpinal cordGeneSodiumPsychiatryBiochemistryOrganic chemistryPain Mechanisms and TreatmentsHereditary Neurological DisordersMusculoskeletal pain and rehabilitation