Maternal obesogenic diet regulates offspring bile acid homeostasis and hepatic lipid metabolism via the gut microbiome in mice
Michael D. Thompson, Jisue Kang, Austin Faerber, Holly Hinrichs, Oğuz Özler, Jamie Cowen, Yan Xie, Phillip I. Tarr, Nicholas O. Davidson
2022American Journal of Physiology-Gastrointestinal and Liver Physiology15 citationsDOIOpen Access PDF
Abstract
We utilized a mouse model of maternal obesogenic diet exposure to evaluate the effect on offspring microbiome and bile acid homeostasis. We identified shifts in the offspring microbiome associated with changes in cecal bile acid levels. Transfer of the microbiome from maternal obesogenic diet-exposed offspring to microbiome-depleted mice altered bile acid homeostasis and increased fructose-induced hepatic steatosis.
Topics & Concepts
OffspringBile acidMicrobiomeGut microbiomeHomeostasisMetabolismEndocrinologyLipid metabolismBiologyGut floraInternal medicineEnergy homeostasisBiochemistryPregnancyMedicineBioinformaticsObesityGeneticsLiver Disease Diagnosis and TreatmentDiet and metabolism studiesDiet, Metabolism, and Disease