Palladium‐Catalyzed Silylacylation of Allenes Using Acylsilanes
Tetsuya Inagaki, Shun Sakurai, Masahiro Yamanaka, Mamoru Tobisu
Abstract
We have developed a palladium-catalyzed addition of a C-Si bond of acylsilanes across a range of unactivated allenes. The reaction proceeds with complete regioselectivity, in which a silyl group binds to the central carbon of the allene, allowing for the straightforward access to functionalized alkenylsilane derivatives.
Topics & Concepts
AlleneRegioselectivityPalladiumSilylationCatalysisChemistryMedicinal chemistryOrganic chemistryCatalytic Cross-Coupling ReactionsOrganoboron and organosilicon chemistryCatalytic C–H Functionalization Methods