A New Avenue for Enhanced Treatment of Hyperuricemia and Oxidative Stress: Design, Synthesis and Biological Evaluation of Some Novel Mutual Prodrugs Involving Febuxostat Conjugated with Different Antioxidants
Aya Y. Rashad, Hoda G. Daabees, Mohamed Elagawany, Mohamed A. Shahin, Ahmed E. Abdel Moneim, Sherif A. F. Rostom
Topics & Concepts
FebuxostatChemistryOxidative stressHyperuricemiaProdrugConjugated systemAntioxidantUric acidOxidative phosphorylationPharmacologyCombinatorial chemistryBiochemistryOrganic chemistryMedicinePolymerGout, Hyperuricemia, Uric AcidPharmacological Effects of Natural CompoundsPlant-derived Lignans Synthesis and Bioactivity