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The Inhibition of H1N1 Influenza Virus-Induced Apoptosis by Surface Decoration of Selenium Nanoparticles with β-Thujaplicin through Reactive Oxygen Species-Mediated AKT and p53 Signaling Pathways

Changbing Wang, Haiyang Chen, Danyang Chen, Mingqi Zhao, Zhengfang Lin, Min Guo, Tiantian Xu, Yi Chen, Liang Hua, Tao Lin, Ying Tang, Bing Zhu, Yinghua Li

2020ACS Omega44 citationsDOIOpen Access PDF

Abstract

. Mechanistic investigation revealed that Se@TP inhibited H1N1 influenza virus from infecting MDCK cells through induction of apoptosis via suppressing AKT and p53 signaling pathways through immunohistochemical assay. Our results suggest that β-thujaplicin-modified SeNPs as carriers are an efficient way to achieve an antiviral pharmaceutical candidate for H1N1 influenza.

Topics & Concepts

ApoptosisInfluenza A virusReactive oxygen speciesIn vivoVirusDNA fragmentationProtein kinase BChemistrySeleniumFragmentation (computing)Signal transductionBiologyProgrammed cell deathBiochemistryVirologyBiotechnologyEcologyOrganic chemistryVitamin C and Antioxidants ResearchReproductive System and PregnancySelenium in Biological Systems
The Inhibition of H1N1 Influenza Virus-Induced Apoptosis by Surface Decoration of Selenium Nanoparticles with β-Thujaplicin through Reactive Oxygen Species-Mediated AKT and p53 Signaling Pathways | Litcius