Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 M<sup>pro</sup>
Vishal M. Balaramnavar, Khurshid Ahmad, Mοhd Saeed, Irfan Ahmad, Mehnaz Kamal, Talaha Jawed
Abstract
. This validated approach may help in finding the urgently needed drugs for the SARS-CoV-2 pandemic with infinitesimal chances of failure.
Topics & Concepts
RepurposingPharmacophoreDrug repositioningCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Pharmacology2019-20 coronavirus outbreakChemistryCombinatorial chemistryComputational biologyMedicineDrugStereochemistryVirologyBiologyInternal medicineInfectious disease (medical specialty)OutbreakDiseaseEcologyComputational Drug Discovery MethodsSARS-CoV-2 and COVID-19 ResearchPharmacological Receptor Mechanisms and Effects