Glutathione-triggered biodegradable poly(disulfide)s: ring-opening copolymerization and potent antibacterial activity
Jia Guo, Siqi Zhang, Yaqi Tao, Baoer Fan, Wen Tang
Abstract
To combat multidrug-resistant bacteria, GSH-responsive cationic amphiphilic poly(disulfide)s as mimics of host defense peptides have been designed and they demonstrated potent antibacterial activity and responsive degradation.
Topics & Concepts
GlutathioneDisulfide bondAmphiphileCationic polymerizationAntibacterial activityChemistryCopolymerGlutathione disulfideBacteriaCombinatorial chemistryPolymer chemistryBiochemistryOrganic chemistryBiologyEnzymePolymerGeneticsAntimicrobial agents and applicationsAntimicrobial Peptides and ActivitiesBiopolymer Synthesis and Applications