Aptamer single-molecule dispersion on single-atom anchoring sites for high-selectivity <i>in vivo</i> detection
Jing Huang, Shiting Gu, Xue Zhou, Yibin Liu, Zhonghai Zhang
Abstract
in different brain regions of living mice. This advancement has revolutionized our understanding of DA variation in the prefrontal cortex of Parkinson's disease (PD) mice. In contrast to previous beliefs, we have discovered a new neurotransmitter dynamic pattern: while the total concentration of neurotransmitters decreases, the concentration of DA remains constant, thus not affecting cognitive levels. This finding is crucial for a more targeted understanding of PD and opens avenues for more effective treatments and diagnostic methods.
Topics & Concepts
AptamerAnchoringSelectivityMoleculeDispersion (optics)In vivoChemistryMaterials scienceNanotechnologyBiologyCatalysisOpticsMolecular biologyBiochemistryPhysicsOrganic chemistryBiotechnologyEngineeringStructural engineeringAdvanced biosensing and bioanalysis techniquesMolecular Sensors and Ion DetectionMolecular Junctions and Nanostructures