Tilorone confers robust in vitro and in vivo antiviral effects against severe fever with thrombocytopenia syndrome virus
Jing‐Jing Yang, Yunzheng Yan, Qingsong Dai, Ji‐Ye Yin, Lei Zhao, Yuexiang Li, Wei Li, Wu Zhong, Ruiyuan Cao, Song Li
Abstract
• Tilorone dihydrochloride possesses robust anti-SFTSV activity in vitro and in vivo. • Intraperitoneal administration of tilorone leads to protection against intracranial lethal challenge of SFTSV. • The anti-SFTSV mechanism of tilorone is through stimulation of host innate immunity. • Pre-treatment with tilorone can prevent mice from lethal SFTSV challenge.
Topics & Concepts
In vivoIn vitroVirologyImmunityMedicinePharmacologyBiologyImmunologyImmune systemBiochemistryBiotechnologyViral Infections and VectorsViral Infections and Outbreaks ResearchMosquito-borne diseases and control