GnRH replacement rescues cognition in Down syndrome
María Manfredi-Lozano, V Leysen, Meredith Adamo, Isabel Paiva, Renaud Rovera, Pignat JM, Timzoura FE, Michael Candlish, Sabiha Eddarkaoui, M. Glória de Sá, Silva MSB, Sara Trova, Mónica Imbernón, Laurine Decoster, L Cotellessa, Manuel Tena‐Sempere, Marc Claret, Ariane Paoloni‐Giacobino, Damien Plassard, Emmanuelle Paccou, Nathalie Vionnet, James S. Acierno, Maceski AM, Antoine Lutti, Frank W. Pfrieger, Sowmyalakshmí Rasika, F Santoni, Ulrich Boehm, Philippe Ciofi, Luc Buée, Nasser Haddjeri, Boutillier AL, Jens Kühle, Andrea Messina, Bogdan Draganski, Paolo Giacobini, Nelly Pitteloud, Vincent Prévot
Abstract
Brief summary: This study identified a new role for GnRH in higher brain function using a rodent model of Down Syndrome. It reports for the first time an improvement of cognitive functions in patients with Down Syndrome treated with pulsatile GnRH.