Novel combretastatin A-4 derivative containing aminophosphonates as dual inhibitors of tubulin and matrix metalloproteinases for lung cancer treatment
Xiaochao Huang, Yuanhang Chen, Wentian Zhong, Zhikun Liu, Haijiang Zhang, Bin Zhang, Heng‐Shan Wang
Topics & Concepts
ChemistryApoptosisA549 cellMatrix metalloproteinaseTubulinPharmacologyCancer cellIn vivoCancer researchCytotoxic T cellBiochemistryIn vitroMicrotubuleCancerCell biologyBiologyGeneticsBiotechnologyOrganophosphorus compounds synthesisSynthesis and biological activityPI3K/AKT/mTOR signaling in cancer