Reactive oxygen species-upregulating nanomedicines towards enhanced cancer therapy
Yuanyuan Ding, Qingqing Pan, Wenxia Gao, Yuji Pu, Kui Luo, Bin He
Abstract
concentrations in cancer cells, including the efficient delivery of natural enzymes, nanozymes, small molecular biological molecules, and nanoscale Fenton-reagents and semiconductors and neutralization of intracellular antioxidant substances and localized input of mechanical and electromagnetic waves (such as ultrasound, near infrared light, microwaves, and X-rays). The applications of these ROS-upregulating nanosystems in enhancing and synergizing cancer therapies including chemotherapy, chemodynamic therapy, phototherapy, and immunotherapy are surveyed. In addition, we discuss the challenges of ROS-upregulating systems and the prospects for future studies.
Topics & Concepts
Reactive oxygen speciesCancer therapyCancerChemistryOxygenCancer researchMedicineBiochemistryInternal medicineOrganic chemistryNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisNanoparticle-Based Drug Delivery