Pathophysiological role and potential drug target of NLRP3 inflammasome in the metabolic disorders
Huiming Hu, Shuwen Wang, Chen Chen
Abstract
NLRP3 plays a role in the development of autoinflammatory diseases. NLRP3, ASC, and Caspases 1 or 8 make up the NLRP3 inflammasome, which is an important part of innate immune system. The NLRP3 inflammasome-mediated inflammatory cytokines may also participate in metabolic disorders, such as diabetes, hyperlipidemia, atherosclerosis, non-alcoholic fatty liver disease, and gout. Hence, an overview of the NLRP3 regulation in these metabolic diseases and the potential drugs targeting NLRP3 is the focus of this review.
Topics & Concepts
InflammasomeInnate immune systemHyperlipidemiaMedicineFatty liverDrugDiabetes mellitusInflammationImmune systemDiseaseGoutImmunologyBioinformaticsPharmacologyBiologyInternal medicineEndocrinologyInflammasome and immune disordersLipid metabolism and disordersCholesterol and Lipid Metabolism