tRNA methylation resolves codon usage bias at the limit of cell viability
Isao Masuda, Yuka Yamaki, Rajesh Detroja, Somnath Tagore, Henry Moore, Sunita Maharjan, Yuko Nakano, Thomas Christian, Ryuma Matsubara, Todd M. Lowe, Milana Frenkel‐Morgenstern, Ya‐Ming Hou
Abstract
G37 inactivates this neutralization and exposes the need for a minor isoacceptor for cell viability. This work has medical implications for bacterial species that exclusively use the major isoacceptor for survival.
Topics & Concepts
Transfer RNALimit (mathematics)MethylationComputational biologyBiologyDNA methylationGeneticsCodon usage biasGeneGenomeGene expressionMathematicsRNAMathematical analysisRNA modifications and cancerRNA and protein synthesis mechanismsGenomics and Phylogenetic Studies