Cisplatin and doxorubicin chemotherapy alters gut microbiota in a murine osteosarcoma model
Zhi Tian, Xiaochen Qiao, Zhichao Wang, Xiaoyan Li, Yongchun Pan, Xiaochun Wei, Zhi Lv, Pengcui Li, Qiujing Du, Wenhao Wei, Lei Yan, Song Chen, Chaojian Xu, Yi Feng, Ruhao Zhou
Abstract
in the osteosarcoma animal model group returned to normal after CDDP or DOX treatment. Furthermore, the function of the gut microbiota was inferred through PICRUSt2 (Phylogenetic Investigation of Communities by Reconstruction of Unobserved States), which indicated that metabolism-related microbiota was highly enriched and significantly different in each group. These results indicate correlations between dysbiosis of the gut microbiota and osteosarcoma growth and chemotherapy treatment with CDDP or DOX and may provide novel avenues for the development of potential adjuvant therapies.