Three-Stage Pooled Plasma Hepatitis C Virus RNA Testing for the Identification of Acute HCV Infections in At-Risk Populations
Hsin‐Yun Sun, Chieh Chiang, Sung‐Hsi Huang, Wen-Jin Guo, Yu‐Chung Chuang, Yi‐Chia Huang, Chia‐Jui Yang, Li‐Hsin Su, Yi-Ting Chen, Yea‐Wen Chen, Fu‐Chiang Hsu, Shu‐Yuan Ho, Wen‐Chun Liu, Yi‐Ching Su, Sui‐Yuan Chang, Chin‐Fu Hsiao, Chien‐Ching Hung, Ming‐Lung Yu
Abstract
Our three-stage pooled plasma HCV RNA testing successfully identified HCV viremia in high-risk PLWH with a testing cost reduction of 84.5%. Simulation analysis offered detailed information regarding the selection of pool and mini-pool sizes in settings of different HCV epidemiology and the performance of HCV RNA testing to optimize the cost reduction.
Topics & Concepts
ViremiaMedicineHepatitis C virusStage (stratigraphy)Hepatitis CInternal medicineIncidence (geometry)Viral loadHepacivirusImmunologyVirologyVirusBiologyOpticsPhysicsPaleontologyHepatitis C virus researchHIV/AIDS drug development and treatmentHIV-related health complications and treatments