Polysaccharide-Based Nanoparticles for Colon-Targeted Drug Delivery Systems
Yubia De Anda-Flores, Elizabeth Carvajal‐Millán, Alma C. Campa-Mada, Jaime Lizardi‐Mendoza, Agustín Rascón‐Chu, J. Tánori, Ana L. Martínez‐López
Abstract
Polysaccharide biomaterials have gained significant importance in the manufacture of nanoparticles used in colon-targeted drug delivery systems. These systems are a form of non-invasive oral therapy used in the treatment of various diseases. To achieve successful colonic delivery, the chemical, enzymatic and mucoadhesive barriers within the gastrointestinal (GI) tract must be analyzed. This will allow for the nanomaterials to cross these barriers and reach the colon. This review provides information on the development of nanoparticles made from various polysaccharides, which can overcome multiple barriers along the GI tract and affect encapsulation efficiency, drug protection, and release mechanisms upon arrival in the colon. Also, there is information disclosed about the size of the nanoparticles that are usually involved in the mechanisms of diffusion through the barriers in the GI tract, which may influence early drug degradation and release in the digestive tract.