Systemic delivery of a targeted synthetic immunostimulant transforms the immune landscape for effective tumor regression
Caitlyn L. Miller, Idit Sagiv-Barfi, Patrick Neuhöfer, Debra K. Czerwinski, Steven E. Artandi, Carolyn R. Bertozzi, Ronald Levy, Jennifer R. Cochran
Topics & Concepts
Tumor microenvironmentImmune systemImmunotherapyCancer researchImmunostimulantCD8TLR9CpG OligodeoxynucleotideImmunologySystemic administrationMedicineBiologyIn vivoDNA methylationGeneBiochemistryBiotechnologyGene expressionImmunotherapy and Immune ResponsesImmune Cell Function and InteractionImmune cells in cancer