Indole-3-acetamide from gut microbiota activated hepatic AhR and mediated the remission effect of <i>Lactiplantibacillus plantarum</i> P101 on alcoholic liver injury in mice
Meng-Qi Wang, Xiaoyan Feng, Yu Zhao, Yuzhi Lan, Hengyi Xu
Abstract
L. plantarum P101 alleviated alcoholic liver damage by regulating gut microbiota and its metabolites. The altered metabolite indole-3-acetamide activated the AhR signaling pathway and alleviated alcoholic injury in HepG2 cells.
Topics & Concepts
Gut floraLiver injuryImmunologyBiologyPharmacologyChemistryAlcohol Consumption and Health EffectsGut microbiota and healthLiver Disease Diagnosis and Treatment