Expression of Human Endogenous Retrovirus Group K (HERV-K) HML-2 Correlates with Immune Activation of Macrophages and Type I Interferon Response
Eric Russ, Natallia Mikhalkevich, Sergey Iordanskiy
Abstract
and correlates with interferon gamma signaling activity in cutaneous leishmaniasis patients. This study provides key insights into the HML-2 subgroup and suggests that it may participate in enhancing pro-inflammatory signaling in macrophages and probably other immune cells.
Topics & Concepts
BiologyInterferonEndogenous retrovirusInnate immune systemChromatin immunoprecipitationGeneticsInterferon type IInterferon regulatory factorsGeneImmune systemGene expressionGenomePromoterChromosomal and Genetic VariationsRNA Research and SplicingRNA and protein synthesis mechanisms