Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases
Haobai Liu, Quan Wang, Yue Huang, Yue Huang, Jinhui Deng, Xi Xie, Jiaqi Zhu, Yijun Yuan, Yueming He, Yi‐You Huang, Yi‐You Huang, Hai‐Bin Luo, Xixin He
Topics & Concepts
PharmacologyInflammatory bowel diseaseChemistryRoflumilastInflammatory Bowel DiseasesNauseaMedicineGastroenterologyInternal medicineDiseasePulmonary diseaseMulticomponent Synthesis of HeterocyclesPhosphodiesterase function and regulationTuberculosis Research and Epidemiology