The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells
Lisa Reisbeck, Benedikt Linder, Georg Tascher, Süleyman Bozkurt, Katharina J. Weber, Christel Herold‐Mende, Sjoerd J. L. van Wijk, Rolf Marschalek, Liliana Schaefer, Christian Münch, Donat Kögel
Abstract
Induction of cell-lethal autophagy represents a possible strategy to combat glioblastoma (GBM). Here, we demonstrate that the novel iron chelator and OXPHOS inhibitor VLX600 exerts pronounced tumor cell-killing effects in adherently cultured GBM cells and glioblastoma stem-like cell (GSC) spheroid cultures that depend on the iron-chelating function of VLX600 and on autophagy activation, underscoring the context-dependent role of autophagy in therapy responses. VLX600 represents an interesting novel drug candidate for the treatment of this tumor.
Topics & Concepts
AutophagyMitophagyContext (archaeology)Programmed cell deathCancer researchCellCell cultureGlioblastomaCell biologyBiologyChemistryApoptosisBiochemistryGeneticsPaleontologyAutophagy in Disease and TherapyExtracellular vesicles in diseaseMicroRNA in disease regulation