Tfap2b specifies an embryonic melanocyte stem cell that retains adult multifate potential
Alessandro Brombin, Daniel J. Simpson, Jana Trávníčková, Hannah Brunsdon, Zhiqiang Zeng, Yuting Lu, Adelaide I.J. Young, Tamir Chandra, E. Elizabeth Patton
Abstract
McSCs have multifate potential, and are the cells of origin for large patches of adult melanocytes, two other pigment cell types (iridophores and xanthophores), and nerve-associated cells. Hence, Tfap2b confers McSC identity in early development, distinguishing McSCs from other neural crest and pigment cell lineages, and retains multifate potential in the adult zebrafish.
Topics & Concepts
BiologyZebrafishMelanocyteStem cellNeural crestEmbryonic stem cellCell biologyHair follicleCellular differentiationPopulationAdult stem cellEmbryoGeneticsGeneMelanomaSociologyDemographymelanin and skin pigmentationCancer-related molecular mechanisms researchSingle-cell and spatial transcriptomics