Rapid Estimation of Binding Constants for Cucurbit[8]uril Ternary Complexes Using Electrochemistry
Jia Liu, Hugues Lambert, Yong‐Wei Zhang, Tung‐Chun Lee
Abstract
-G2 ternary complexes and their reported binding constants from isothermal titration calorimetry, which allow a calibration curve to be plotted based on 25 sample complexes. Mechanistic investigation using experimental and computational approaches reveals that this correlation stems from the dynamic host-guest exchange events occurring after the electron transfer step. Binding constants of unknown ternary complexes, where G2 = hydrocarbons, were estimated, illustrating potential applications for sparsely soluble second guests.
Topics & Concepts
Ternary operationChemistryIsothermal titration calorimetrySupramolecular chemistryBinding constantTitrationElectrochemistryThermodynamicsHomogeneousComputational chemistryPhysical chemistryMoleculeBinding siteOrganic chemistryElectrodeComputer scienceProgramming languagePhysicsBiochemistrySupramolecular Chemistry and ComplexesCrystallography and molecular interactionsMolecular Sensors and Ion Detection