Host defense peptide mimicking cyclic peptoid polymers exerting strong activity against drug-resistant bacteria
Wenjing Zhang, Shuai Deng, Min Zhou, Jingcheng Zou, Jiayang Xie, Ximian Xiao, Ling Yuan, Zhemin Ji, Sheng Chen, Ruxin Cui, Zhengjie Luo, Guixue Xia, Runhui Liu
Abstract
, displays strong antibacterial activities against drug-resistant bacteria, but low hemolysis and cytotoxicity. In addition, the mode-of-action study indicates that the antibacterial mechanism is associated with bacterial membrane interaction. Our study implies that HDP mimicking cyclic peptoid polymers have potential application in treating drug-resistant bacterial infections.
Topics & Concepts
PeptoidHemolysisBacteriaChemistryAntibacterial activityPeptidePolymerDrugCyclic peptidePolymerizationCytotoxicityBiological activityCombinatorial chemistryBiophysicsBiochemistryBiologyIn vitroOrganic chemistryPharmacologyGeneticsImmunologyAntimicrobial Peptides and ActivitiesAntimicrobial agents and applicationsClick Chemistry and Applications