Imidazothiazole-based potent inhibitors of V600E-B-RAF kinase with promising anti-melanoma activity: biological and computational studies
Hanan S. Anbar, Mohammed I. El‐Gamal, Hamadeh Tarazi, Bong S. Lee, Hong R. Jeon, Dow Kwon, Chang‐Hyun Oh
Abstract
induces apoptosis not necrosis in the most sensitive melanoma cell line, UACC-62. Furthermore, molecular dynamic and 3D-QSAR studies were done to investigate the binding mode and understand the pharmacophoric features of this series of compounds.
Topics & Concepts
MelanomaKinaseCancer researchPharmacologyChemistryComputational biologyMedicineBiologyBiochemistryMelanoma and MAPK PathwaysComputational Drug Discovery MethodsSynthesis and biological activity