Artemongolides A–F, undescribed sesquiterpenoid dimers from <i>Artemisia mongolica</i> and their antihepatic fibrosis activities
Chong Shang, Xiaoyan Huang, Yuan Wang, Wei Dong, Xiao-Feng He, Tian-Ze Li, Ji‐Jun Chen
Abstract
Six rare sesquiterpenoid dimers were isolated from Artemisia mongolica . Compound 1 exhibited inhibitory activity against HSC-LX2 cells with an IC 50 value of 165.0 μM, equivalent to that of the positive control silybin (IC 50 , 144.4 μM).
Topics & Concepts
ChemistryArtemisiaStereochemistryPositive controlTraditional medicineBotanyBiologyMedicineSesquiterpenes and Asteraceae StudiesSilymarin and Mushroom PoisoningPlant Toxicity and Pharmacological Properties