The Anticancer Agent 3,3'-Diindolylmethane Inhibits Multispecies Biofilm Formation by Acne-Causing Bacteria and Candida albicans
Yong‐Guy Kim, Jin‐Hyung Lee, Jin‐Hyung Lee, Sunyoung Park, Jintae Lee, Jintae Lee
Abstract
Since indoles are widespread in nature (even in human skin), we hypothesized that indole and its derivatives might control biofilm formation of acne-causing bacteria ( Cutibacterium acnes and Staphylococcus aureus ) and fungal Candida albicans . The present study reports for the first time the antibiofilm and antimicrobial activities of several indoles on C. acnes .
Topics & Concepts
BiofilmCandida albicansBacteriaMicrobiologyAcneChemistryBiologyGeneticsOral microbiology and periodontitis researchAntifungal resistance and susceptibilityBacterial biofilms and quorum sensing