Inhibition of TGFβ1 accelerates regeneration of fibrotic rat liver elicited by a novel two-staged hepatectomy
Bo Zhang, Fanzheng Meng, Yao Liu, Yubin Yuan, Jizhou Wang, Dehai Wu, Yifeng Cui, Shugeng Zhang, Hongrui Guo, Shuhang Liang, Wei Wang, Matthew Klos, Sherry Morgenstern, Yufeng Liu, Linmao Sun, Kun Ma, Xirui Liu, Yan Wang, Jihua Han, Guangchao Yang, Chenyang Zheng, Xianying Li, Shuo Zhou, Changyong Ji, Qingquan Bai, Jiabei Wang, Lianxin Liu
Abstract
Inhibition of TGFβ1 accelerated regeneration of fibrotic liver, ameliorated liver fibrosis, and improved liver function following ALPPS. Therefore, TGFβ1 is a promising therapeutic target in ALPPS to improve fibrotic liver reserve function and prognosis.
Topics & Concepts
Liver regenerationHepatectomyRegeneration (biology)Transforming growth factorPathologyChemistryCell biologyCancer researchMedicineBiologySurgeryResectionLiver physiology and pathologyPancreatic and Hepatic Oncology ResearchTGF-β signaling in diseases