Positive feedback loop of miR-320 and CD36 regulates the hyperglycemic memory-induced diabetic diastolic cardiac dysfunction
Jiabing Zhan, Kunying Jin, Nan Ding, Yufei Zhou, Hu Guo, Shuai Yuan, Rong Xie, Wen Zheng, Chen Chen, Huaping Li, Dao Wen Wang
Abstract
in DM-induced cardiac injury, miR-320 and CD36 mutually enhance each other's expression, leading to a positive feedback loop and a sustained hyperlipidemic state in the heart.
Topics & Concepts
CD36DiastoleInternal medicineGene knockdownMedicineEndocrinologyGlycemicType 2 diabetesInsulinDiabetes mellitusIn vivoCardiologyReceptorBiologyBlood pressureCell cultureBiotechnologyGeneticsPancreatic function and diabetesCardiovascular Function and Risk FactorsSignaling Pathways in Disease