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Targeting PP2A with lomitapide suppresses colorectal tumorigenesis through the activation of AMPK/Beclin1-mediated autophagy

Qian Zuo, Long Liao, Zi-Ting Yao, Yaping Liu, Ding-Kang Wang, Shujun Li, Xingfeng Yin, Qing‐Yu He, Wenwen Xu

2021Cancer Letters41 citationsDOI

Topics & Concepts

AutophagyAMPKCancer researchPhosphorylationColorectal cancerPharmacologyMedicineCell biologyChemistryCancerBiologyInternal medicineBiochemistryApoptosisProtein kinase AAutophagy in Disease and TherapyCancer, Lipids, and MetabolismCancer-related molecular mechanisms research
Targeting PP2A with lomitapide suppresses colorectal tumorigenesis through the activation of AMPK/Beclin1-mediated autophagy | Litcius