Rapid Intestinal Uptake and Targeted Delivery to the Liver Endothelium Using Orally Administered Silver Sulfide Quantum Dots
Nicholas J. Hunt, Glen P. Lockwood, Frank H. Le Couteur, Peter McCourt, Nidhi Singla, Sun Woo Sophie Kang, Andrew Burgess, Zdenka Kuncic, David G. Le Couteur, Victoria C. Cogger
Abstract
clathrin- and caveolae-mediated pathways with QDs taken up into lysosomes. In conclusion, we have shown high specificity targeting of the LSEC or hepatocytes after oral administration of QDs coated with a biopolymer layer of FSA or gelatin, which improved the bioavailability and delivery of metformin to LSECs.
Topics & Concepts
EndocytosisBiopolymerChemistryBiophysicsClathrinGelatinBioavailabilityQuantum dotIn vivoBiochemistryPharmacologyMaterials scienceNanotechnologyBiologyCellOrganic chemistryPolymerBiotechnologyAdvanced Drug Delivery SystemsQuantum Dots Synthesis And PropertiesInfant Nutrition and Health